FUMED SILICA (ADDITIVE) FOR PHARMACEUTICALS

COLLOIDAL ANHYDROUS SILICA APPLICATION IN PHARMACEUTICALS

Colloidal anhydrous silica (Fumed silica), a highly versatile material, finds widespread applications as an excipient in the pharmaceutical industry. It effectively addresses challenges related to poor flowability of particles and powders, difficulties in tablet blending and compression, as well as aesthetic concerns. colloidal silicon dioxide offers several key functions and benefits, including:

Improved Flowability:

Enhances the flow characteristics of particles and powders during manufacturing processes.
Ensures smooth and consistent production flow.

Tablet Production:

Acts as a lubricant and anti-adherent to prevent tablet sticking and ease tablet release from molds.
Facilitates the production of well-formed tablets with precise dosing and appealing appearance.

Emulsion and Suspension Stabilization:

Functions as a stabilizer in milk-like emulsions and cloudy suspensions.
Maintains formulation stability, preventing phase separation and ensuring uniform dispersion of active ingredients.

Drug Carrier and Absorption Enhancement:

Serves as a carrier for drugs, prolonging their efficacy.
Facilitates drug absorption in the body, promoting enhanced therapeutic effects.

Types of Paints/ Coating

Function of Fumed Silica

Flow Aid

Improves the flowability of particles and powders, enhancing their ability to flow and be compressed.

Lubricant

Facilitates smooth tablet compression, aiding in uniform tablet feeding and achieving a glossy and appealing tablet surface.

Binder

Promotes cohesive bonding of pharmaceutical ingredients, facilitating easy tablet ejection and ensuring accurate dosage with a clean and attractive tablet surface.

Sustained Release Agent

Enables controlled release of drugs in the body, prolonging drug efficacy, extending drug action duration, and promoting drug absorption.

Disintegrant

Absorbs water and swells, causing the tablet’s binding forces to break, leading to fragmentation into smaller particles within the gastrointestinal tract, thus facilitating therapeutic effectiveness.